BioWorld looks at translational medicine, including: Adapting NGS for coronavirus surveillance; Long QT genes mostly short on evidence; Reservoir dogs don’t hunt; Another reason to get a flu shot; Cerebrospinal fluid is early culprit in stroke edema; Different drivers can turn the wheel in glioblastoma’s vicious cycle; From African genomes, big insights with small sample size; Commercial antibodies underwhelm for studies of PP2A; Tau keeps gliomas in check.
Keeping you up to date on recent developments in neurology, including: Improving memory with noninvasive electrostimulation successfully studied in mice; AI analysis can predict progression of neurodegenerative disease from blood test; Study finds that after stroke, brain drowns in its own fluid; Immune response in brain, spinal cord could offer clues to treating neurological diseases.
DUBLIN – The witty Twitter account @justsaysinmice, run by Northeastern University research scientist Jim Heathers, offers a very useful corrective to the misleading and unwarranted hype that often accompanies preclinical studies in mice. What looks good in murine models is all too often lost in translation, for a whole host of reasons, and never has any useful effect in patients. That’s not a concern for a group led by Thomas Thum, of the Institute of Molecular and Translational Therapeutic Strategies at Hannover Medical School in Germany, who just published in Nature Communications the outcome of what is probably the largest ever pig study in heart failure.
Keeping you up to date on recent developments in diagnostics, including: Increasing early disease detection; Adapting NGS for coronavirus surveillance; AD and HHV: Still a mystery; Increasing accuracy of malaria diagnoses
When developmental neurobiologist Arnold Kriegstein talks about his work, it sounds for all the world like he is talking about the brains of teenagers. They are stressed. Their identity is mixed up. But putting them in a good environment is helpful to their development. Kriegstein, though, was describing brain organoids.
Keeping you up to date on recent developments in orthopedics, including: Tiny salamander's huge genome may harbor the secrets of regeneration; New injection technique may boost spinal cord injury repair efforts; ACL tears cause harmful changes in brain structure
Keeping you up to date on recent developments in oncology, including: SABR showing promise for spinal metastases; Chromosome amplification drives cancer progression via effects on secretion; IMRT shows well in study of upper-tract urothelial carcinoma
Australian researchers led by the Garvan Institute of Medical Research in Sydney have compiled the first reference genome database of healthy older Australians, which potentially can predict disease-linked gene variants more accurately than has been previously possible.
An international collaborative study led by geneticists at the Queensland Institute of Medical Research Berghofer Medical Research Institute (QIMR) in Brisbane, Australia, has used a multivariate approach to develop a polygenic risk score (PRS) for glaucoma.
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