Positive findings from an initial Phase III study of pain candidate Ampion drove shares of Ampio Pharmaceuticals Inc. (NYSE:AMPE) higher Wednesday. Patients in the Phase III SPRING study in osteoarthritis of the knee (OAK) treated with a single intra-articular injection of the non-steroidal immunomodulator achieved clinically meaningful reduction in pain. Investors took notice, sending shares of the Greenwood Village, Colo.-based company up 30 percent at the opening bell.