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Home » Topics » Disease categories and therapies » Cancer

Cancer
Cancer RSS Feed RSS

Avmapki-Fakzynja packaging

High-graded low-grade ovarian duo wins for Verastem at FDA

May 9, 2025
By Randy Osborne
Verastem Oncology Inc. CEO Dan Paterson said he is “not expecting a huge bolus [of ovarian cancer patients] at the beginning” of Avmapki/Fakzynja’s launch, but momentum will build over time. “Based on our market research, this [drug] is the most likely thing for them to go on next,” he added, noting that patients tend to be on the drug for an average of 18 months.
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Cancer

PTPN2/PTP1B degraders disclosed in Northridge Health patent

May 9, 2025
Northridge Health Group (Hong Kong) Co. Ltd. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a tyrosine-protein phosphatase non-receptor type 2 (PTPN2; TCPTP)/PTP1B-targeting moiety via a linker.
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Cancer

Neuboron Medtech Research Institute patents new agents for boron neutron capture therapy

May 9, 2025
Neuboron Medtech Research Institute Ltd. has disclosed boron-containing lipoic acid derivatives and vesicle forms acting as boron neutron capture therapy (BNCT) agents reported to be useful for the treatment of cancer.
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Immuno-oncology

SYS-6041 shows promise for treating FOLR1-expressing cancers

May 9, 2025
Folate receptor α (FOLR1) is highly expressed in the surface of tumoral cells in several cancer types, while it shows limited expression in normal tissues. CSPC Pharmaceutical Group Ltd. has developed a next-generation antibody-drug conjugate (ADC) targeting FOLR1 – SYS-6041 – for the treatment of mid-to-low FOLR1-expressing tumors.
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3D illustration and light micrograph of lung cancer.
Immuno-oncology

mRNA-based cancer vaccine targeting mutated EGFR shows antitumor efficacy

May 9, 2025
Drug resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, occurring via secondary mutations or bypass pathways, is frequent among non-small-cell lung cancer patients.
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Immuno-oncology

Anti-CLDN6 QLS-5132 found to have broader therapeutic window

May 9, 2025
Claudin-6 (CLDN6) is a protein found in the tight junctions of epithelial cells to modulate their permeability and barrier function, among other actions.
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Immuno-oncology

Aptevo Therapeutics advances APVO-711 for solid tumors

May 9, 2025
Aptevo Therapeutics Inc. is advancing APVO-711, its bispecific antibody targeting PD-L1 x CD40 that combines checkpoint inhibition with immune activation in a single molecule.
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Cancer

Chinese researchers unveil new agent for KRAS G12D-mutated tumors

May 9, 2025
The KRAS G12D mutation is the most common oncogenic KRAS variant, identified in approximately 34% of pancreatic ductal adenocarcinoma cases, 12% of colorectal cancers and 4% of lung adenocarcinomas.
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Illustration of cancer tumor
Cancer

UTR Therapeutics files IND application for UTRxM1-18 for c-MYC-driven cancers

May 9, 2025
UTR Therapeutics Inc. has submitted an IND application to the FDA for UTRxM1-18, a novel therapeutic approach for targeting c-MYC-driven cancers. Pending approval, a first-in-human phase I trial is slated to begin next year.
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Cancer

An oncolytic adenovirus to potentiate immune checkpoint inhibitor therapy against renal cell carcinoma

May 9, 2025
Approximately 90% of all kidney cancers involve renal cell carcinoma, against which researchers are racing to find more effective therapies. One of the major challenges in treating this and other cancers is ensuring that the immune cells that infiltrate the tumor remain activated and mount effective responses.
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