Researchers from Jinggangshan University reported on the synthesis of a series of novel celastrol derivatives that led to the identification of [I] as the main compound with water solubility of 11.8 mg/mL and antiproliferative effects accounting for IC50 values of 0.58, 0.32, 0.32, 0.75, 0.29 and 4.30 µM against BEL-7402, AGS, HCT 116, HepG-2, MGC-803 and A549 human cancer cell lines, respectively.