On June 17, the FDA approved checkpoint blocker Keytruda (pembrolizumab, Merck & Co. Inc.) “for the treatment of adult and pediatric patients with unresectable or metastatic tumor mutational burden-high (TMB-H) [?10 mutations/megabase (mut/Mb)] solid tumors, as determined by an FDA-approved test, that have progressed following prior treatment and who have no satisfactory alternative treatment options.”
BioWorld looks at translational medicine, including: Liver-derived protein helps lung, kidney repair; Multiracial study gives new diabetes insights; New way to target drugs, independently of drug target; Microbiome-produced metabolites improve gut health; Universal flu vaccine more challenging than anticipated; The bow ties that bind; FOXO1 regulates HIV latency; Patient genetic variants linked to wound microbiomes; New COPD target.
Keeping you up to date on recent developments in diagnostics, including: Improving diagnosis of pulmonary hypertension; A web-based COVID-19 assessment tool; Discovering pharmacological enzyme activators.
By targeting chimeric antigen receptors (CARs) to a senescence marker, researchers at Memorial Sloan-Kettering Cancer Center have developed a CAR T cell that had beneficial effects in mouse models of both liver fibrosis and lung cancer.
Keeping you up to date on recent developments in orthopedics, including: Osteoporosis treatment also may protect against pneumonia; Study finds similar short-term outcomes after common MI spine procedures; New biomaterial has potential to repair damaged bone with lower risk of inflammation; Diabetics face greater risk of bone fractures.
The disconnect between the need for sleep and the possession of a brain is what prompted Dragana Rogulja, an assistant professor of neurobiology in the Blavatnik Institute at Harvard Medical School, and her team to take a look at multiple tissues in sleep-deprived flies and mice.
Keeping you up to date on recent developments in oncology, including: 3D-printed reservoir + magnetic sponge = new way to beat cancer; HRAS-driven translation helps skin prevent tumors; NETS and mets; Observational study supports cryoablation for RCC.
Keeping you up to date on recent developments in cardiology, including: Assessing who’s at risk for heart rhythm disorders; Rewiring the heart to prevent recurrent fainting spells; Understanding link between COVID-19, cardiovascular diseases.
Keeping you up to date on recent developments in neurology, including: Three stages to COVID-19 brain damage identified; ApoE4’s role in Alzheimer’s blood vessels; Lifespan synaptic atlas gives developmental insights.
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