An international collaborative study led by U.S and Chinese scientists was the first to show that the extracellular autophagy regulator, sequestosome-1, mediates septic death in mice by activating insulin receptor signaling in macrophages and monocytes.
TORONTO – What’s the difference between an organ transplant container tucked under a paramedic’s arm and an ordinary beer cooler packed with ice? Surprisingly, not much, according to researchers at London, Ontario’s Western University. They’ve come up with a portable, temperature-controlled container that prevents spoilage of donor organs during transport to the operating room – and of potential vaccines.
Keeping you up to date on recent developments in cardiology, including: Biobeat's wearable monitoring device shows promise in swine model; Neutrophils are literal obstacle to stroke recovery; Neovessel formation eyed in treating cardiovascular diseases.
A multi-institutional team of researchers has implicated lipid droplets, which are key energy storage units of individual cells, in innate immune defense.
Keeping you up to date on recent developments in neurology, including: Study highlights links between inflammation and Parkinson’s disease; Some sedentariness in older adults OK when it comes to brain, cognition; Microbiome metabolite affects neuropathic pain; Following neonatal lead enables spinal cord repair in mice.
Investigators at the ECOG-ACRIN Cancer Research Group and the National Cancer Institute reported a roughly 40% match rate of patients to molecularly targeted therapies in its NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) trial, ultimately leading to molecularly targeted treatments for almost 20% of trial participants.
Keeping you up to date on recent developments in diagnostics, including: Remote speech analysis detects early bulbar changes in ALS; Novel NGS approach captures both mtDNA mutation and copy number; Neutrophils are literal obstacle to stroke recovery.
“It’s coming. We know it’s coming.” That was Nevan Krogan’s blunt reminder that SARS-CoV-2 is not the first virus to wreak temporary havoc on humanity, nor will it be the last.
A Chinese study is the first to identify fibroblast activation protein (Fap) as an osteogenic suppressor that could be targeted to prevent osteoporosis and has shown that osteolectin, a bone glycoprotein that binds calcium, is an endogenous Fap inhibitor promoting bone mineralization.
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