Heidelberg, Germany-based Affimed NV described its progress at the American Association for Cancer Research meeting and discussed the research in a conference call on 2020 financial results, adding fuel to investor enthusiasm for the firm’s natural killer (NK) cell approach, although the update did not come without some confusion.
A collection of CAR T-cell programs originally licensed by Precision Biosciences Inc. to Baxalta Inc. in a $1.6 billion deal are, after handoffs to Shire and Servier SAS, back where they began. Precision said April 15 it would reacquire all development and commercial rights to the programs, including two clinical-stage CD19-targeting allogeneic CAR T candidates, from Servier for $1.25 million in cash, plus the waiver of earned but as-yet unpaid milestones totaling $18.75 million.
Organoids cultured from patient-derived colorectal cancer cells have been used to demonstrate for the first time that tumors which have developed resistance to the full range of existing treatments, across chemotherapies, targeted therapies and immunotherapies, retain a requirement for Werner helicase (WRN) for survival.
New and updated preclinical and clinical data presented by biopharma firms at the American Association for Cancer Research Annual Meeting 2021, including: Adagene, Antengene, Ascentage, Beigene, Bluebird, Celcuity, Celldex, Eli Lilly, Geneleap, Greenwich, Heat, Immunocore, Immunogen, Innovent, Psioxus, Replimune, Sotio, Sound, Spectrum, SQZ, Sumitomo, Synthekine, Tachyon, Taiho, Tallac, TCR2, Theratechnologies, Treovir, Trisalus, Ultimovacs, Vincerx, Xencor, Y-mabs, Zentalis, Zymeworks.
Theseus Pharmaceuticals Inc., a startup developing new tyrosine kinase inhibitors to overcome treatment-resistant cancer mutations, has raised $100 million in a series B financing led by Foresite Capital. Co-founded at the health care investment firm Orbimed with former Ariad Pharmaceuticals Inc. scientists who pioneered the development of pan-variant kinase inhibitors, the company's lead candidate is THE-630, a next-generation pan-variant KIT inhibitor for the potential treatment of refractory gastrointestinal stromal tumors.
New and updated preclinical and clinical data presented by biopharma firms at the American Association for Cancer Research Annual Meeting 2021, including: BMS, Kronos, Kymera, Medicenna, Medigene, Mei, Mersana, Mirati, Molecular Partners, Molecular Templates, Morphic, Nextcure, Nuvalent, Oasmia, Oncolytics, Oncomyx, Oncurious, Oncternal, Oric, Pharmabcine, Phio, Pieris, PMV, Puretech, Schrodinger, Seneca.
In a move that Sanofi SA said will bring it an mRNA-based research platform with applications in oncology, immunology and other diseases, the company has acquired Tidal Therapeutics Inc. for $160 million up front and up to $310 million in milestone payments. The preclinical startup, led by Merrimack Pharmaceuticals Inc. and Torque Therapeutics Inc. co-founder Ulrik Nielsen, is based in Cambridge, Mass.
New and updated preclinical and clinical data presented by biopharma firms at the American Association for Cancer Research Annual Meeting 2021, including: Achilles, Advaxis, Affimed, Agenus, Alpine, Amphivena, Amunix, Arch, Arcus, Bayer, Beigene, Bio-Path, Black Diamond, Briacell, C4, Cardiff Oncology, Checkmate, Clovis, Codiak, Crispr, Elevation, Eli Lilly, Essa, F-star, Fusion, Gennao, Genprex, Glycomimetics, Gracell, GT, Hookipa, Hummingbird, Mirati, Instil, Intra-Cellular, Immune-Onc, Immunogen, Iteos, Jubilant, Kezar, Kineta, Kintara.
Cachexia, Teresa Zimmers told the audience at the Annual Meeting of the American Association for Cancer Research (AACR), is "woefully understudied for the outsized impact it has on cancer patients." The condition, which is currently defined as weight loss and muscle wasting, is the direct cause of death in an estimated 25% to 30% of cancer patients. But it is the main subject of only 0.1% of research papers and 0.2% of clinical trials.
New and updated preclinical and clinical data presented by biopharma firms at the American Association for Cancer Research Annual Meeting 2021, including: Affimed, Atyr, Chemocentryx, Greenwich, Humanigen, Imcheck, In8bio, Iovance, Mina, Nimbus, Onxeo, Sana, Sanofi, Surface Oncology, Transgene, Turning Point.
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