Researchers from University of Toronto and affiliated organizations have presented the discovery and preclinical evaluation of novel inhibitors of fungal fatty acid biosynthesis as potential antifungal agents. High-throughput screening of a library of natural products against representative isolates of four major human pathogenic yeast species (Candida albicans, C. glabrata, C. auris, C. neoformans) resulted in the discovery of the triazenyl indole NPD-6433.
An experimental vaccine that contained antigens of both lytic and latent phases of Epstein-Barr virus (EBV), and induced both an antibody and a T cells response, was able to generate broad and long-lasting immunity against EBV in mouse models of infection. Researchers from the QIMR Berghofer Medical Research Institute and Elicio Therapeutics Inc. reported those results online in Nature Communications on Aug. 8, 2023.
For some viruses, the challenge to developing a vaccine is their rapid mutation rate. This is the major challenge to developing an HIV vaccine or a universal flu vaccine. EBV is different. Its superpower is its ability to hide.
Human schistosomiasis is caused by parasitic flatworms in the genus Schistosoma, with the three major species that cause this disease being S. mansoni, S. haematobium, and S. japonicum. In the current study, researchers from University of Texas Health Science Center San Antonio presented preclinical data for novel oxamniquine (OXA) derivatives as potential new candidates for the treatment of this neglected tropical disease.
It has gone unnoticed in HIV research until now, but a transcriptomic analysis has detected a molecule that could kill this virus. Scientists at a U.S. military research institute laboratory have found a common factor in human cells that inhibited the replication of HIV-1 in people living with the virus. “Without any manipulation of cells in people with HIV, we have found a host factor that is inhibiting HIV in vivo,” the senior author Rasmi Thomas, chief of the Laboratory of Integrative Multiomics at Walter Reed Army Institute of Research, told BioWorld. Using single cell RNA sequencing (scRNA-seq), the study published on Aug. 2, 2023, in Science Translational Medicine identified this host factor as prothymosin α, a protein isolated from the thymus in 1966 and described in 1984.
Centre Hospitalier Regional Universitaire de Lille and Centre National de la Recherche Scientifique have patented norbornene analogues reported to be useful for the treatment of tuberculosis.
A study of the genetic determinants of HIV viral load in 3,879 people of African ancestries has found what is claimed to be the only new variant related to HIV infection discovered in more than two decades of research into how host genomics affects the response to the retrovirus.
Researchers from Laboratoire Biodim presented the discovery of novel HIV-1 integrase-LEDGF allosteric inhibitors (INLAIs), designed to share the binding site on the viral protein with the host factor LEDGF/p75. INLAIs act as molecular glues to promote hyper-multimerization of HIV-1 integrase protein to produce defective progeny virions, and as such, severely disrupt maturation of viral particles.
Evaxion Biotech A/S has presented promising results on EVX-B1, a vaccine against Staphylococcus aureus containing antigens identified using artificial intelligence. EVX-B1 induces strong immune responses, both cellular and humoral, that translate to a high level of protection in preclinical models for skin infection and sepsis.
Suzhou Ark Biopharmaceutical Co. Ltd. researchers have prepared and tested heteroaromatic bicyclic compounds reported to be useful for the treatment of respiratory syncytial virus (RSV) infection.
Colonization of the stomach by the bacterium Helicobacter pylori can cause gastric cancer by secreting the CagA oncoprotein. Now, a Japanese laboratory has discovered that CagA disrupted Wnt/PCP signaling and altered the polarity in which the squamous cells of the developing gastric epithelium are arranged, causing the hyperproliferation of the stem cells.
RSS
