Previous reports have disclosed the development of Shigella conjugate vaccines (SCVs) using a platform squaric acid chemistry conjugation approach and carrier protein recombinant fragment of tetanus toxin heavy chain (rTTHc).
Researchers from Universidad Carlos III de Madrid presented the development and preclinical characterization of a novel specific radiotracer for the diagnosis of Clostridioides difficile infection (CDI).
With the U.S. FDA’s approval of Orlynvah (sulopenem etzadroxil and probenecid) for uncomplicated urinary tract infections, Iterum Therapeutics plc can move on from regulatory delays and prepare to launch only the second FDA-approved treatment for the indication in the past 20 years.
Siga Technologies Inc. has entered into an agreement with Vanderbilt University to obtain a license to a portfolio of preclinical fully human monoclonal antibodies (MAbs) which could be used as potential treatments for a broad range of orthopoxviruses, including smallpox and mpox.
Studies evaluating the in vitro and in vivo antifungal activity, hemolytic activity and cytotoxicity of COT-832, a novel polyene macrolide antifungal that is a chemical modification of amphotericin B (AmB), were presented at IDWeek by Shionogi & Co. Ltd.
Evotec International GmbH and Nosopharm SAS have jointly described odilorhabdin analogues reported to be useful for the treatment of multidrug-resistant bacterial infections.
The influenza virus undergoes rapid and frequent antigen shifts that usually force seasonal vaccine updating. The mismatch between vaccine strains and circulating viruses leads to limited vaccine effectiveness, mainly in immunocompromised and older individuals.
Patients receiving a kidney transplant and who are positive for BK virus (BKV) are at risk of losing their transplant due to BKV reactivation. At this time, there are no antiviral options available for the prevention of BKV-associated nephropathy. Researchers from Aicuris Anti-infective Cures GmbH presented preclinical data on AIC-468, an antisense RNA therapy that inhibits the splicing process of a viral mRNA encoding a protein critical for BKV replication.
Bioversys AG has joined the EU-funded RespiriNTM program that is exploring multiple approaches to determine new targets for antimycobacterial compounds, define and optimize novel inhibitors and advance these through the process of hit-to-lead up until first-in-human trials.
Clostridioides difficile, a spore-forming and anaerobic gram-positive bacterium, causes a wide-spectrum diarrheal disease that can ultimately lead to life-threatening conditions such as toxic megacolon or colonic perforation.
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