Sionna Therapeutics Inc.’s approach with small molecules in cystic fibrosis (CF) yielded the Boston-based firm an upsized and oversubscribed $182 million series C financing. The company is working on drugs that could fully restore the function of the CF transmembrane conductance regulator protein by stabilizing the first nucleotide-binding domain (NBD1). Four compounds are expected to enter the clinic this year – three NBD1 stabilizers and one ICL4 modulator.

Foreign investment in China’s biopharma sector is beginning to pick up after the hit of severe pandemic restrictions, and as Western governments look to revive trading relationships following a spate of diplomatic rows. While the geopolitical tensions remain, the mantra from Europe is not to de-couple, but to de-risk. Following a policy review in 2023, the U.K. government position is that a positive two-way trade and investment relationship with China is “mutually beneficial.”

Biopharmas raising money in public or private financings, including: Akero, Alumis, Apogee, Bridgebio, Celldex, Innocan, Me, Nyrada, Oxurion, Scilex, Xeris.

Med-tech firms raising money in public or private financings, including: Braincheck, Eisai, Nalu.

Biopharmas raising money in public or private financings, including: Akero, Arcutis, Armata, Bridgebio, Innoviva, Mithra, Quoin, Viking, Xbrane.

Med-tech firms raising money in public or private financings, including: Limbic.

Biopharmas raising money in public or private financings, including: Biovie, Heidelberg, Nektar, Nocion, Oragenics, Revance, Xortx.

Med-tech firms raising money in public or private financings, including: Cryocloud, Envoy Medical, Phagenesis, Shape Memory.

With its sights set on expanding the commercial launch of Xdemvy (lotilaner ophthalmic solution, 0.25%) to treat Demodex blepharitis in the U.S., Tarsus Pharmaceuticals Inc. has priced an underwritten public offering of common stock, selling 2.8 million shares for $32 each, taking the expected gross proceeds to about $100 million.