Aurigene Oncology Ltd. has described proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to a probable global transcription activator SNF2L2 (SMARCA2; BAF190B; SNF2-α) and/or transcription activator BRG1 (SMARCA4; BAF190A; SNF2-β) targeting moiety via a linker acting as SMARCA2 and/or SMARCA4 degradation inducers reported to be useful for the treatment of cancer.
Youngene Therapeutics Co. Ltd. has divulged glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of type 2 diabetes, obesity, prediabetes, metabolic syndrome, stroke, metabolic dysfunction-associated steatohepatitis, cardiovascular and renal disorders, among others.
Guangzhou Henovcom Bioscience Co. Ltd. has synthesized prodrugs of rotigotine reported to be useful for the treatment of restless legs syndrome, depression and Parkinson’s disease.
Beijing Double-Crane Runchuang Technology Co. Ltd. has disclosed protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.
Setonix Pharmaceuticals has described peroxisome proliferator-activated receptor γ (PPARγ) modulators reported to be useful for the treatment of inflammatory disorders, metabolic syndrome, obesity, viral infection, cancer, lipid metabolism and glucose metabolism disorders.
Lysoway Therapeutics Inc. has synthesized mucolipin-1 (MCOLN1; TRPML1) activators reported to be useful for the treatment of age-related macular degeneration, aging, Alzheimer’s disease, cancer, Charcot-Marie-Tooth disease, cystic fibrosis, muscular dystrophy and type C Niemann-Pick disease.
Scientists at Meta Pharmaceutical (HK) Ltd. and Shenzhen Moyuan Pharmaceuticals Co. Ltd. have disclosed lactate dehydrogenase A (LDHA) inhibitors reported to be useful for the treatment of cancer, allergy, among others.
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