Evotec International GmbH has disclosed integrin α4β7 (LPAM-1) antagonists reported to be useful for the treatment of ulcerative colitis and Crohn’s disease.
A patent from F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. describes bicyclic heterocycle 5'-nucleotidase (CD73) inhibitors reported to be useful for the treatment of cancer.
Gruenenthal GmbH has patented new cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives acting as nociceptin receptor (OPRL1; KOR3; ORL1) agonists and thus reported to be useful for the treatment of pain.
Sanofi SA has synthesized pyridoimidazolone compounds acting as mitogen-activated protein kinase 7 (MAPK7; ERK5) inhibitors potentially useful for the treatment of cancer.
Work at Horizon Omics Biotech Ltd. has led to the identification of quinolone derivatives reported to be useful for the treatment of cancer, autoimmune diseases, viral, bacterial and fungal infections.
Shanghai Synergy Pharmaceutical Sciences Co. Ltd. and Zhejiang Huahai Pharmaceutical Group Co. Ltd. have patented C-C chemokine receptor type 4 (CCR4) antagonists reported to be useful for the treatment of cancer, autoimmune diseases and inflammatory disorders.
Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have synthesized salts of complement factor B (CFB) inhibitors reported to be useful for the treatment of allergy, asthma, age-related macular degeneration, inflammatory disorders, stroke, Parkinson’s, Crohn’s diseases and hepatic fibrosis, among others.
A joint Korea Research Institute of Chemical Technology and Novartis AG patent describes antiviral 1,3-di-oxo-indene compounds reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease, diabetes, hepatitis A, viral infection, myocarditis, myositis and pancreatitis, among others.
Aeovian Pharmaceuticals Inc. has prepared tricyclic fused imidazole compounds acting as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) inhibitors reported to be useful for the treatment of neurodegeneration, inflammation, fibrosis, systemic scleroderma and more.
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