It was a busy day at Moderna Inc. as Merck & Co. Inc. exercised its option to jointly develop and commercialize a personalized cancer vaccine with Moderna in a deal the two companies inked in 2016. Moderna also notched another emergency use authorization (EUA) for its COVID-19 vaccine, this one targeting the omicron variant, for use by those under age 18.
Aim Vaccine Co. Ltd. priced an IPO on the Hong Kong Stock Exchange, raising HK$70.01 million (US$9 million) to fund work on its late-stage vaccine pipeline. Its shares increased only 3.09% on debut Oct. 6 but closed the week at HK$24.80, up 54% over its listing price of HK$16.16.
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Everest, GSK, HDT, Innovent, Nanoscope, Novelmed, Pfizer, Scpharmaceuticals, Supernus.
Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Brooklyn, Cara, Christianacare, Cocrystal, Corrixr, Compass, Eli Lilly, Enteris, Eterna, ICER, Karuna, Merck and Co., Muna, Nimbus, Psychogenics, SWK and Synergys.
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Actinogen, Ascletis, Brainstorm, G1, Hutchmed, Immatics, Iovance, Janssen, Merck KGaA, Morphic, Sciwind, Tenax.
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Alnylam, Diurnal, Hugel, Knight, Lyell, Revive.
Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Beigene, Biontech, Evonik, Gennisium, Immune-Onc, Merck, Phathom, Pierre Fabre, Ridgeback, Teva.
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Allogene, Clarity, Icosavax, Mersana, Octapharma, Oravax, Prolynx.
The factors why the clinical outcomes during infection with SARS-CoV-2 virus are highly heterogenous remains poorly understood. Apolipoprotein E (APOE) is a secreted protein with roles in lipid metabolism; interestingly, APOE has been shown to modulate immunity, including infection and antitumor immunity.
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