Scientists at Duke University School of Medicine in Durham, N.C., have developed a small-molecule inhibitor of the cellular stress-protective transcription factor, heat-shock factor 1, which showed developmental promise against treatment-resistant prostate cancer and other cancers. The small molecule, Direct Targeted HSF1 InhiBitor (DTHIB), may also be a useful research tool for investigating the regulation and role of HSF1 in basic stress biology and in cancer.
A U.S. study has shown for the first time that enhancing signals from the nociceptive nervous system could provide new approaches to improve the collection of hematopoietic stem cells (HSCs) for treating cancers of the blood and bone marrow.
Scientists at Duke University School of Medicine in Durham, North Carolina, have developed a small-molecule inhibitor of the cellular stress-protective transcription factor, heat-shock factor 1, which showed developmental promise against treatment-resistant prostate cancer and other cancers.
Korean researchers at Sungkyunkwan University in Seoul have demonstrated that regenerative medicine using multipotent mesenchymal stem cell-derived extracellular vesicles could mitigate intraventricular hemorrhage-induced brain damage in newborn rats.
Scientists at Duke University School of Medicine in Durham, North Carolina, have developed a small-molecule inhibitor of the cellular stress-protective transcription factor, heat shock factor 1 (HSF1), which showed developmental promise against treatment-resistant prostate cancer and other cancers.
In terms of cellular diversity, it may not be the brain, but the kidney boasts more cell types than most other organs. Now, researchers have used single-cell RNA sequencing to identify further subtypes of cells in the kidney, and gain new insights into the molecular mechanisms of chronic kidney disease.
A multicenter in vivo Japanese "transomics" analysis led by scientists at the University of Tokyo has revealed previously unknown allosteric and genetic regulatory axes underlying the altered hepatic glucose-responsive metabolism seen in obesity.
An international study led by Nanyang Technological University in Singapore has designed and synthesized broad-spectrum antimicrobial polymers (AMPs) and demonstrated the safety and efficacy of two such agents against multidrug-resistant (MDR) bacteria in mouse models of sepsis.
A study by Japanese scientists at the Okinawa Institute of Science and Technology has found that serotonergic neural projections to the brain's orbitofrontal and medial prefrontal cortices differentially modulate patience, as assessed by the time spent awaiting future rewards in mice.
Combining metabolic intervention with T-cell immunotherapy is safe and resulted in improved efficacy in two mouse models of solid tumors, providing an alternative combination strategy for boosting solid tumor immunotherapy, according to a new study by scientists at China Pharmaceutical University.
