Pregnane X receptor (PXR) is a transcription factor that plays a crucial role in maintaining bile acid homeostasis by regulating major metabolizing enzymes and transporters.
Hepatic ischemia-reperfusion injury (HIRI) is a common leading cause of liver injury and is associated with several clinical conditions, including liver transplantation, liver resection surgeries and cancer, among others.
Asialoglycoprotein receptor 1 (ASGR1) is a transmembrane protein specifically expressed in hepatocytes that plays a key role in maintaining circulating glycoprotein homeostasis.
Researchers from Inipharm Inc. presented preclinical data for INI-822, a small-molecule inhibitor of HSD17B13, being developed for the treatment of liver disease.
Acetaminophen (APAP) is a very common nonprescription analgesic, harmless at low doses, that can cause acute liver injury and even death from acute liver failure when overdosed. The temporal course of acetaminophen overdose-induced liver injury (AILI) can be depicted in two stages – injury and recovery.
A high-density lipoprotein (HDL) subspecies produced by small intestine, which potently shields the endotoxicity of bacterial lipopolysaccharide (LPS), may protect against gut-derived liver injury, according to a study led by scientists at Washington University School of Medicine (WUSM) in St. Louis.
