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BioWorld Science

July 3, 2020

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Boehringer Ingelheim begins home-based phase II study of BI-1358894 for MDD

Shock and kill with less toxicity

MANIFEST study results of CPI-0610 in advanced myelofibrosis set up phase III study

Programmed necrosis has role in post-flu bacterial infections

Meissa completes pre-IND meeting for COVID-19 vaccine candidate MV-014-210

Phase III study of pracinostat plus azacytidine in AML discontinued due to lack of efficacy

LAMC2 identified as a therapeutic target in PDAC

Yuhan discovers semicarbazide-sensitive amine oxidase inhibitors

CREDO 2 pivotal global phase III study of olokizumab meets endpoints

New E-NPP 2 inhibitors identified at Roche

Janssen synthesizes new cyclopentyl nucleoside analogues

Spanish approval granted for COVID-19 study using EnteraGam

Heptares Therapeutics identifies new orexin OX1 receptor antagonists

Lilly patents TYK2 JH2 domain ligands

Phase III trial of Kevzara in COVID-19 does not meet primary and key secondary endpoints

FDA approves Rukobia for the treatment of adults with multidrug-resistant HIV-1 infection

First patient dosed in phase II study of ICP-192 for cholangiocarcinoma

FDA approves Byfavo injection for the induction and maintenance of procedural sedation

IBT-V02: Staphylococcus aureus vaccine that confers protection in mouse and rabbit

SGN-B6A demonstrates promising activity in solid tumor models

Discovery and preclinical evaluation of potent FLT3/AXL dual inhibitor, JR-F104

Neuren begins first-in-human study of oral NNZ-2591 in healthy volunteers

First-in-human study evaluates metarrestin in metastatic solid tumors

COVAX-19 begins phase I study in Australia

Modest activity seen with tislelizumab in phase II lymphoma study

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