"We got it wrong," mourned Maxim analyst Jason McCarthy after Waltham, Mass.-based Proteon Therapeutics Inc. disclosed results from the phase III trial called Patency-2, a 603-patient experiment with vonapanitase, made up of recombinant human elastase, in patients with chronic kidney disease (CKD) undergoing creation of radiocephalic (wrist) fistulas for vascular access in hemodialysis.