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Home » Topics » BioWorld Science, Immune

BioWorld Science, Immune
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Immune

New RIPK2 inhibitors disclosed in Chengdu Zeling Biomedical Technology patent

May 23, 2025
Chengdu Zeling Biomedical Technology Co. Ltd. has divulged receptor-interacting serine/threonine-protein kinase 2 (RIPK2; RIP-2) inhibitors reported to be useful for the treatment of autoimmune diseases.
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Respiratory

KT-621: a first-in-class STAT6 degrader for Th2-driven diseases

May 22, 2025
No Comments
STAT6 plays a central role in regulating Th2-driven immune responses. Recent studies have identified gain-of-function mutations in the STAT6 gene that are associated with early-onset, severe allergic diseases. As a result, STAT6 has emerged as a promising therapeutic target in conditions such as asthma, eosinophilic inflammation, food allergies and atopic dermatitis, particularly in cases that are refractory to standard therapies.
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Immune

Shenzhen Zhongge Biotechnology presents IRAK-4 degraders

May 14, 2025
Shenzhen Zhongge Biotechnology Co. Ltd. has described proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding agent coupled to interleukin-1 receptor-associated kinase 4 (IRAK-4) targeting moiety via linkers acting as IRAK-4 degradation inducers reported to be useful for the treatment of cancer, autoimmune disease, inflammatory disorders, transplant rejection, thromboembolism, atherosclerosis, myocardial infarction and metabolic syndrome.
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Immune

Hitgen identifies IL17RA antagonists

May 13, 2025
Hitgen Ltd. has prepared and tested interleukin-17 receptor A (IL17RA; CD217) antagonists reported to be useful for the treatment of autoimmune disease, cancer, infections, asthma, multiple sclerosis, psoriasis, rheumatoid arthritis and inflammatory disorders.
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DNA in drug capsules, digital background
Immune

Ensoma gains IND clearance for in vivo HSC-directed therapy for X-linked chronic granulomatous disease

May 13, 2025
No Comments
Ensoma Inc. has obtained IND clearance from the FDA for its lead program EN-374 in X-linked chronic granulomatous disease (X-CGD).
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Illustration of measles virus particles
Infection

Invivyd initiates measles monoclonal antibody discovery program

May 13, 2025
No Comments
Invivyd Inc. has initiated a discovery program for a measles monoclonal antibody (mAb).
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3d illustration of ovarian cancer
Cancer

Lipid uptake drives immune evasion in high-grade serous ovarian cancer

May 13, 2025
By Coia Dulsat
No Comments
Researchers from Trinity College Dublin, Princeton University and collaborators have discovered that blocking the uptake of lipids by immune cells within the ascites microenvironment could reshape treatment for advanced ovarian cancer.
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Art concept for inflamed human tissue
Immune

Kymera unveils new oral IRF5 degrader for immuno-inflammatory diseases

May 12, 2025
No Comments
Kymera Therapeutics Inc. has announced a new oral IRF5 degrader program with potential to treat immuno-inflammatory diseases, such as lupus, Sjögren’s syndrome, rheumatoid arthritis and inflammatory bowel disease.
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Liver illustration
Endocrine/metabolic

Liver is also immune organ, influenced by microbiome

May 12, 2025
By Anette Breindl
No Comments
Immunity is not a function most people particularly associate with the liver. But because of its connection to the gut, the liver is exposed to bacterial metabolites as few other organs are. And when either the liver or the gut is not functioning well, it can adversely affect immunity as well. The liver is connected to the gut via both the biliary system and the portal vein. Those two conduits allow metabolites from the gut microbiome to influence what’s going on in the liver. Both liver and gut damage can affect this communication for the worse. And surprisingly, one of the consequences is immune dysfunction.
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3D illustration of a liposome
Neurology/psychiatric

Ahead Therapeutics advances myasthenia gravis program toward toxicology studies

May 9, 2025
No Comments
Ahead Therapeutics SL has received positive feedback from the EMA on its way toward initiating regulatory toxicology studies for its lead program in myasthenia gravis. The feedback supports the company’s scientific approach.
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