With its lead cancer drug unpartnered and a new CEO yet to be chosen, Synta Pharmaceuticals Corp. is advancing the phase II/III AML LI-1 trial to test the chemosensitizing mettle of the heat-shock protein 90 inhibitor ganetespib when paired with low-dose cytarabine (Ara-C) in acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome patients who are not eligible for intensive chemotherapy.