Shares of Immune Design Corp. hit an all-time low Friday after the company scrapped phase III testing for one of its two lead candidates, the prime-boost cancer vaccine CMB-305 in synovial sarcoma. Signs that combining it with Tecentriq (atezolizumab, Roche Holding AG) in a phase II trial is unlikely to offer a survival benefit for relapsed synovial sarcoma patients also shaped the decision. All efforts at the West Coast company will now shift to its second lead cancer vaccine, the intratumoral TLR4 agonist G-100.