Sage Therapeutics Inc. sought to emphasize the lessons learned and increased understanding from the top-line readout of its first phase III trial, which assessed brexanolone (SAGE-547) in patients with super-refractory status epilepticus, or SRSE. The highly anticipated trial missed its primary endpoint of comparing the candidate's success in weaning of third-line agents and resolution of potentially life-threatening status epilepticus vs. placebo (43.9 percent vs. 42.4 percent; p=0.8775) when added to standard of care.