Physiologically, antibodies are one of the major weapons the body deploys against infection. And the very first Nobel Prize in Physiology or Medicine, in 1901, was awarded to Emil Adolf von Behring for antibodies (in the form of serum therapy) against the diphtheria-causing Corynebacterium diphtheriae. So it is perhaps surprising that in the 117 years since, as far as antibiotic therapeutics go, small molecules have largely been the name of the game.