TG Therapeutics Inc. will seek to carry two candidates in its pipeline across the goal line in a single play after reaching agreement with the FDA on a special protocol assessment (SPA) for the design of a phase III study combining TG-1101 (ublituximab), its glycoengineered anti-CD20 monoclonal antibody, and TGR-1202, a glycoengineered once-daily phosphoinositide-3-kinase (PI3K)-delta inhibitor, to treat chronic lymphocytic leukemia (CLL).