Realm Therapeutics plc led its second-quarter earnings with a dud: Top-line data from its randomized, double-blind phase II study in atopic dermatitis showed that PR-022 performed no different from placebo, compared to baseline, on the primary endpoint of percent change in Eczema Area Severity Index, or EASI, at day 29. The company did not disclose details. CEO Alex Martin commented only that a full review of the data was underway "to determine whether there is a path forward for our proprietary technology in atopic dermatitis and to evaluate the implications for our acne and psoriasis programs."