Dynavax Technologies Corp. reported Wednesday that top-line data from the Phase III trial comparing its investigational hepatitis B vaccine Heplisav met all three clinical endpoints, demonstrating noninferiority, superiority and safety in comparison to the marketed hep B vaccine Engerix-B (GlaxoSmithKline). Nevertheless, investors failed to respond with enthusiasm, perhaps reflecting nervousness about a second piece of news regarding the company's consistency analysis of manufacturing data.