More than 75 percent of research activity on human proteins continues to focus on the 10 percent of proteins that were known before the mapping of the human genome was completed in 2000, even though many more proteins have been genetically linked to disease during the ensuing decade. Risk-averse funding and peer review systems as well as a dearth of research tools – such as antibodies and chemical inhibitors needed to study proteins – share blame, a group of research scientists posited this week in Nature.