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Home » Myriad study shows discrepancies in Clinvar database for hereditary cancer classification
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Myriad study shows discrepancies in Clinvar database for hereditary cancer classification

April 18, 2017
By Omar Ford
Public genetic databases could have a discrepancy in identifying BRCA1 and BRCA2 variant classifications, which can introduce uncertainty and diminish patient care, according to a study by Myriad Genetics Inc. and researchers from Gradishar from the Feinberg School of Medicine at Northwestern University. The study was published in this month's edition of the journal The Oncologist and results from it show that the Clinvar public database provided discrepant variant classifications more than 26 percent of the time. The Salt Lake City-based company's study evaluated 4,250 BRCA1 and BRCA2 variants.
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