SAN FRANCISCO – Type 2 diabetes often becomes progressively more difficult to manage, moving from prediabetes that can be addressed via weight loss and exercise eventually through requiring multiple daily insulin injections. A novel procedure could offer the opportunity to turn back the clock for type 2 (T2) diabetes patients who are insulin-dependent. Fractyl Laboratories Inc. has developed an outpatient procedure known as duodenal mucosal resurfacing (DMR) that, when used in combination with a GLP-1 receptor agonist drug, can reverse the need for insulin for type 2 diabetes patients who were previously insulin-dependent. That's according to data from a small study presented here on June 9 at the American Diabetes Association's 79th Scientific Sessions.