Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Annexon, Atara, Axcella, Biocryst, C4, Calcimedica, Gelesis, Harpoon, Ionis, Medicinova, Orchard, Orphan Technologies, Puretech, Retrophin, Roche, Silverback, Sumitovant, Urovant.