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BioWorld - Sunday, May 11, 2025
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Home » Fulcrum set to pivot in FSHD? No DUX4 score but secondary goals extolled
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Fulcrum set to pivot in FSHD? No DUX4 score but secondary goals extolled

June 25, 2021
By Randy Osborne
Fulcrum Therapeutics Inc.’s phase IIb data with losmapimod in facioscapulohumeral muscular dystrophy (FSHD) brought renewed hope for patients in what historically has proved a challenging therapeutic space. Though the firm’s oral p38 mitogen-activated protein kinase inhibitor missed its primary biomarker endpoint – changes in DUX4-driven gene expression – other indicators of benefit in the study called ReDUX4 painted a bright picture.
BioWorld Clinical Musculoskeletal

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