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See today's BioWorld MedTech
Home » To escape radiation, tumor cells reversibly damage their DNA
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To escape radiation, tumor cells reversibly damage their DNA

May 2, 2022
By Nuala Moran
Researchers have uncovered a new pathway via which cancer cells evade the effects of radiation by deploying self-inflicted – but reversible – DNA breaks to stop the cell cycle and ensure their survival. The lesions are caused by caspase-activated DNase (CAD), an enzyme involved in DNA fragmentation during cell death. In response to radiation, tumor cells activate CAD, causing genome-wide DNA breaks at sites involved in DNA repair.
BioWorld MedTech Science Cancer

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