A phase II trial this week showed that combining the diabetes drug semaglutide (Novo Nordisk A/S) with a fixed-dose combination of Cagrisema (cagrilintide/semaglutide) led to “numerically higher” reductions in both HbA1c and body weight than either component alone. And on the preclinical side, researchers from the Novo Nordisk Research Center and the Helmholtz Diabetes Center reported that linking the dual PPAR activator tesaglitazar to GLP-1 improved glucose control in male mice. Both bits of news illustrate that GLP-1R agonists, which are also called incretin mimetics and GLP-1 analogs, are likely to continue their success across multiple areas of medical care.