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Home » Topics » BioWorld Science, Dermatologic

BioWorld Science, Dermatologic
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Dermatologic

Hansoh Pharma discloses new c-KIT inhibitors

July 24, 2025
Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have synthesized new mast/stem cell growth factor receptor kit (KIT; c-KIT; CD117) inhibitors reported to be useful for the treatment of urticaria.
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3D rendering of skin cells and elastin with collagen layer
Dermatologic

GAS6-AXL axis activation results in scarless oral wound healing

July 11, 2025
By Xavier Bofill Bruna
No Comments
When injured, the human skin is repaired through a wound-healing process that forms fibrotic scar tissue. Scarring burdens patients at both the functional and esthetic levels, and scars in the craniofacial region in particular can be psychologically damaging for the individual. The principal limitation to developing effective scarring treatments is the limited understanding of the molecular mechanisms behind scar formation and the mechanisms that drive repair without scarring.
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Illustration of diabetic foot ulcer, cross section of wound
Dermatologic

FDA clears Eluciderm’s IND to begin clinical trial of ELU-42

July 9, 2025
No Comments
Eluciderm Inc. has received clearance from the U.S. FDA for its IND to conduct a phase I/IIa open-label study evaluating the safety and efficacy of ELU-42, a topical spray-on solution for open wound healing, in patients with diabetic foot ulcers (DFUs).
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Dermatologic

New MRGPRX2 antagonists disclosed in Humanwell Healthcare patent

July 4, 2025
Humanwell Healthcare (Group) Co. Ltd. has divulged Mas-related G-protein coupled receptor member X2 (MRGPRX2) antagonists reported to be useful for the treatment of pain, autoimmune disease and dermatological disorders.
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Fibroblast illustration
Dermatologic

CYT-997 could be new approach for treating hypertrophic scars

July 4, 2025
No Comments
Chinese investigators have published data from studies investigating CYT-997 for the treatment of hypertrophic scars. CYT-997 is a tubulin polymerization inhibitor that reached phase II clinical development for the treatment of multiple myeloma and glioblastoma multiforme.
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3D illustration of the cross-section of skin layers with atopic dermatitis
Dermatologic

SPT6 maintains epidermal homeostasis in inflammatory skin diseases

June 13, 2025
No Comments
At the ongoing International Society for Stem Cell Research meeting, Chinese researchers reported they demonstrated that SPT6 homolog, histone chaperone and transcription elongation factor (SPT6) promotes epidermal stem/progenitor cells differentiation by facilitating transcriptional elongation, but its role in vivo in skin homeostasis is not well defined.
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Illustration of pill being analyzed
Respiratory

Deepcure nominates oral selective STAT6 inhibitor as development candidate

June 11, 2025
No Comments
Deepcure Inc. has nominated DC-15442, an oral selective STAT6 inhibitor, as its second development candidate. DC-15442 is designed to replicate the safety and efficacy of dupilumab, while offering an oral alternative to regular subcutaneous injections.
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Dermatologic

Alys Pharmaceuticals submits CTA for ALY-301 for cold urticaria

June 10, 2025
No Comments
Alys Pharmaceuticals Inc. has submitted a clinical trial application (CTA) to Germany’s Paul-Ehrlich-Institut (PEI) to initiate a phase I/Ib study of ALY-301 in healthy volunteers and patients with cold urticaria, a subtype of chronic inducible urticaria.
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Dermatologic

Biogen patents new TYK2 inhibitors

June 6, 2025
Biogen Inc. has disclosed non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of stroke, psoriasis, arthritis, pain, silicosis, alopecia and more.
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Close up image of shoulder and back with severe urticaria or hives
Dermatologic

Aqilion reports results for TAK1 program in skin inflammation studies

June 6, 2025
No Comments
Aqilion AB has released promising results from new studies with molecules from the company’s lead series within the TAK1 program, demonstrating a strong disease-modifying effect in a well-established model of skin inflammation.
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