In 2021, Ardem Patapoutian won the Nobel Prize in Physiology or Medicine for his discovery of the mechanosensitive receptors Piezo1 and Piezo2. The receptors, which are ion channels that respond to mechanical pressure, are important in touch sensation, as well as regulating processes including bladder control and blood pressure. Now, investigators at The Hospital for Sick Children in Toronto, Canada, and Central South University’s Xiangya Hospital have discovered a decidedly ignoble role for Piezo2.