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See today's BioWorld ScienceSee today's BioWorld
Home » APOE4 allele reduces myelination in Alzheimer’s disease
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Neurology/Psychiatric

APOE4 allele reduces myelination in Alzheimer’s disease

Nov. 16, 2022
By Mar de Miguel
Carrying the apolipoprotein E4 allele (APOE4), and not the APOE3 variant, is the strongest risk factor for developing Alzheimer’s disease (AD). But the underlying mechanism has remained elusive. Now, researchers at MIT and Mount Sinai have found that in brains carrying the APOE4 allele, lipid and cholesterol processes were dysregulated in oligodendrocytes and that this effect reduced myelination.
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