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Breaking News: Trump administration impacts continue to roil the life sciences sectorSee today's BioWorld Science
Home » Anti-siglec-6 MAbs show promise for treating anaphylaxis
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Immune

Anti-siglec-6 MAbs show promise for treating anaphylaxis

Dec. 1, 2022
Mast cells (MCs) are tissue-resident immune cells and are responsible for allergic and inflammatory processes. One potential approach for targeting MCs is to engage inhibitory receptors that can silence MC activation, such as sialic acid-binding immunoglobulin-like lectins (siglecs). Siglec-6 is an inhibitory receptor expressed on human MCs and represents an attractive therapeutic target for this purpose. Siglec-6 engagement with a monoclonal antibody (MAb) was recently shown to inhibit MC activation in vitro.
BioWorld Science Immune Monoclonal antibody

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