Cas12a2 elicits abortive infection and can be repurposed as an RNA-guided RNA-targeting tool
Jan. 20, 2023
Bacterial abortive infection is a defense mechanism by which an infected bacterial cell enters dormancy or dies to limit phage replication and protect the clonal population. Recent studies observed that CRISPR RNA-guided adaptive immune systems that target RNA also cause abortive-infection phenotypes by activating indiscriminate nucleases.