SGLT2 inhibition ameliorates endothelial dysfunction tied to ALDH2*2 variant
Jan. 30, 2023
About 8% of the worldwide population carries the aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant (ALDH2*2, rs671), which has been tied to an increased risk of coronary artery disease (CAD) due to severe loss of ALDH2 enzymatic activity.