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Home » Evelo’s path in AD not EASI as placebo response garbles SINTAX of phase II effort
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Evelo’s path in AD not EASI as placebo response garbles SINTAX of phase II effort

Feb. 1, 2023
By Randy Osborne
Evelo Biosciences Inc.’s late-stage efforts with EDP-1815 are forging ahead despite unfavorable data in atopic dermatitis (AD), and talks so far with the U.S. FDA have proven encouraging, the company said. Cambridge, Mass.-based Evelo made public findings from the first three cohorts of the phase II trial with EDP-1815 in AD, where the compound fell short of the primary endpoint: proportion of patients who achieve an outcome of at least a 50% improvement from baseline in Eczema Area and Severity Index (EASI) score compared to placebo at week 16. Evelo blamed an unusually high placebo response rate.
BioWorld Clinical Dermatologic

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