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Breaking News: Trump administration impacts continue to roil the life sciences sectorSee today's BioWorld Science
Home » Reactivation of fetal protein can lead to improved diabetic wound healing
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Endocrine/Metabolic

Reactivation of fetal protein can lead to improved diabetic wound healing

Feb. 2, 2023
By Subhasree Nag
Researchers at Indiana University School of Medicine are exploring avenues to heal wounds by identifying proteins that are active in fetuses, but largely inactive in adults and absent in diabetic adults. They have identified a protein called nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase, or NPGPx, that fits the bill and could be the basis for therapies aimed at diabetic wound healing. NPGPx is a direct transcriptional target of miR-29. miR-29 is downregulated in fetal tissue, thus NPGPx is active in fetal tissue but becomes mostly inactive in the skin after birth.
BioWorld Science Diabetes Endocrine/metabolic Wound closure

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