Targeting plasma ASM protects against several neuropathological features in AD mice
April 13, 2023
Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide. Previous studies revealed high activity of ASM in the blood and brain of old vs. young individuals or mice, and they implicated this enzyme in neurodegenerative disease pathology.