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Breaking News: Trump administration impacts continue to roil the life sciences sectorSee today's BioWorld Science
Home » Loss of cyclin D3 function reduces DMD pathogenesis in mdx mouse model
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Neurology/Psychiatric

Loss of cyclin D3 function reduces DMD pathogenesis in mdx mouse model

June 29, 2023
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder affecting roughly 1 in 3,500 males. DMD is due to mutations in the dystrophin gene, which encodes for an exceptionally large 427 kD protein. DMD is characterized by repeated degeneration and regeneration of muscle fibers, but ultimately replacement of muscle with fibrotic and adipose tissue. Despite advances in gene therapy and improvements in quality of life, most patients still die by 30 years of age due to cardiopulmonary failure.
BioWorld Science Genetic/congenital Neurology/psychiatric

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