Researchers from Laboratoire Biodim presented the discovery of novel HIV-1 integrase-LEDGF allosteric inhibitors (INLAIs), designed to share the binding site on the viral protein with the host factor LEDGF/p75. INLAIs act as molecular glues to promote hyper-multimerization of HIV-1 integrase protein to produce defective progeny virions, and as such, severely disrupt maturation of viral particles.