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Breaking News: 100 days of uncertaintySee today's BioWorld Science
Home » Epitope engineering shields HSCPs from CD123-targeted immunotherapy
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Immuno-oncology

Epitope engineering shields HSCPs from CD123-targeted immunotherapy

Oct. 9, 2023
Finding suitable antigens for immunotherapy of myeloid malignancies, particularly acute myeloid leukemia (AML), is an urgent clinical need. Most AML candidate targets, including CD123, are co-expressed by hematopoietic stem and progenitor cells (HSCPs), with the subsequent risk of myelosuppression associated with myeloid cell-targeted chimeric antigen receptor (CAR) T therapy.
BioWorld Science Cancer Immuno-oncology

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