Colorectal cancer (CRC) is a heterogeneous malignancy that starts with the sequential transformation of normal mucosa to adenoma and finally to carcinoma, when it attains metastatic potential. The most frequent metastatic site in CRC is the liver. Researchers from Nanjing Medical University and collaborators identified a significant overexpression of procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3) in liver metastasis tissue samples.