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Breaking News: Trump administration impacts continue to roil the life sciences sectorSee today's BioWorld Science
Home » DCC-3116 overcomes ULK1/2-mediated autophagy, shows strong combination efficacy in preclinical models
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Cancer

DCC-3116 overcomes ULK1/2-mediated autophagy, shows strong combination efficacy in preclinical models

March 22, 2024
Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are enzymes that play a key role in initiating and regulating autophagy, with ULK1/2 autophagy being an adaptive stress response to multiple cancer therapies, supporting cell proliferation and tumor progression. At the recently concluded ACS meeting in New Orleans, Deciphera Pharmaceuticals LLC presented the discovery of a first-in-class ULK1/2 inhibitor as a potential new anticancer agent.
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