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Breaking News: Trump administration impacts continue to roil the life sciences sectorSee today's BioWorld Science
Home » Australian scientists explore MERTK as a target against organ fibrosis
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Endocrine/Metabolic

Australian scientists explore MERTK as a target against organ fibrosis

April 9, 2024
By Mar de Miguel
A small molecule could provide a new therapeutic approach against organ fibrosis. Using genome-wide association (GWA) assays, a group of researchers from the Westmead Institute for Medical Research in Sydney identified Mer tyrosine kinase (MERTK) as a candidate to study fibrosis and showed that its inhibition with the experimental compound reduced this condition in mouse models’ liver, kidneys and lungs. “There were some studies on the role of MERTK in liver fibrosis, but its therapeutic potential for various organ fibrosis has not been explored before. This study provides unequivocal evidence that MERTK is a potent nodal regulator of fibrosis supported by detailed mechanistic studies,” the senior author Mohammed Eslam told BioWorld.
BioWorld Science Endocrine/metabolic Inflammatory

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