Targeting the endocannabinoid system and, specifically, inhibiting the degradation of endocannabinoid 2-arachidonoylglycerol (2-AG) has demonstrated a neuroprotective effect in multiple sclerosis (MS). In this sense, monoacylglycerol lipase (MAGL), the enzyme that regulates 2-AG in the brain, has been proposed as a therapeutic target for MS.