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» S1PR4 inhibition prevents disease progression in murine Alport syndrome
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Nephrology
S1PR4 inhibition prevents disease progression in murine Alport syndrome
Oct. 30, 2024
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The knockout of
Col4a3
in mice is used as a model of Alport syndrome. Knockout mice develop glomerular disease associated with neutral lipid accumulation in the kidney and progressive renal failure, which can be treated with lipid-lowering agents.
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