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BioWorld - Tuesday, November 12, 2024
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» SOS1 inhibitor HM-99462 demonstrates synergy with RTK-KRAS-MAPK signaling inhibitors
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Cancer
SOS1 inhibitor HM-99462 demonstrates synergy with RTK-KRAS-MAPK signaling inhibitors
Nov. 8, 2024
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SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS, and recent preclinical studies have demonstrated that combining KRAS and EGFR inhibitors with SOS1 inhibitors can overcome resistance and achieve durable responses.
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